Recently, according to Mohou.com, Professor Luo Binghong’s team from the School of Chemistry and Materials of Jinan University worked on “ACS Nano》 (Influence factor18,027) published on “Bone ECM-like 3D printing scaffold with liquid crystalline and viscoelastic microenvironment for bone regeneration“Important research results (Fig.1）。
Implantation in a bone defect3DPrinted scaffolds provide an effective strategy for personalized bone defect repair. As a key factor in determining the success of bone tissue engineering, scaffold materials must have both a suitable microenvironment for bone regeneration and excellent mechanical properties. In fact, the most ideal osteogenic microenvironment is undoubtedly the natural bone extracellular matrix (DUDE), which has unique liquid crystalline and viscoelastic characteristics. However, how to convert bone-like imagesDUDEThe organic combination of a microenvironment and three-dimensional scaffolds with excellent mechanical properties still poses a significant challenge.
Professor Luo Binghong’s team constructed a new type of bionic bone tissue engineering scaffold material, which combines bone-like elements.DUDEmicroenvironment and robust3DThe printed backing fits perfectly. The team initially succeeded3DPrints and mustachesLBLSelf-assembly, a class of materials with exceptional mechanical properties has been obtained3Da scaffold subsequently printed, for the first time, a boneDUDELiquid crystal hydrogel composite of liquid crystalline and viscoelastic natural polysaccharide and introduce it into solid material3DPrint scaffolds to bionically build bone-like structures in three-dimensional scaffoldsDUDEThe microenvironment, at the same time, uses a liquid crystal composite hydrogel to encapsulate and slowly release the angiogenic factors. This unique microenvironment endows the scaffold with excellent osteogenic and angiogenic activities, effectively promoting the reconstruction of new bone. The study was designed to have a bony appearanceDUDEBone tissue engineering scaffold materials with microenvironment and excellent mechanical properties have opened a new approach.
△Received by natural boneDUDEinspiring3DDesign ideas for printing bionic vascularized bone tissue engineering scaffolds
Professor Luo Binghong, School of Chemistry and Materials, Jinan University, is the sole corresponding author of the article, School of Chemistry and Materials.2021Liu Kun, a doctoral student, is the first author of the article. This research work has received strong support from national general projects, provincial general projects and provincial science and technology planning projects.
Link to full text of the article:DOI:10.1021/acsnano.2c08699
Source: Chinese 3D Printing Network
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